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Global Clinical Trials for Alzheimer’s Disease: Chapter 21. Application of Pharmacogenomics in Global Alzheimer’s Disease Clinical Trials and Ethical Implications

Sidney A. Spector




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 |  2013-08-28 |  2013-08-28 | File type: PDF

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Decades ago, pharmacogenetic research established that one’s genetic profile might predict efficacy and safety of medicines. Polymorphic expression of isoenzymes of the cytochrome P-450 enzyme system explains a significant amount of the variability of inter-individual responses to medicines. In Alzheimer’s disease, the highly variable clinical response to cholinesterase inhibitors metabolized by the liver is explained on this basis. More recently, translation...

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